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Lots of the NBOMe compounds have high potency agonist action at additional 5-HT receptors and extended activation of 5-HT2B might cause cardiac valvulopathy in higher doses and Long-term use.
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Dealing with 25I-NBOMe poses considerable risks as a consequence of its toxicity, necessitating protecting actions such as masks and gloves. The drug carries a superior threat of overdose, with documented cases of acute toxicity and fatalities.
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As a relatively newer compound, it has acquired interest amid scientific researchers for its large binding affinity and complex psychoactive properties.